The condition of synchronous generators (SGs) is a matter of great attention, because they can be seen as equipment and also as fundamental elements of power systems. Thus, there is a growing interest in new technologies to improve SG protection and maintenance schemes. In this context, electrical signature analysis (ESA) is a non-invasive technique that has been increasingly applied to the predictive maintenance of rotating electrical machines. However, in general, the works applying ESA to SGs are focused on isolated machines. Thus, this paper presents a study on the condition monitoring of SGs in bulk electric systems by using ESA. The main contribution of this work is the practical results of ESA for fault detection in in-service SGs interconnected to a power system. Two types of faults were detected in an SG at a Brazilian hydroelectric power plant by using ESA, including stator electrical unbalance and mechanical misalignment. This paper also addresses peculiarities in the ESA of wound rotor SGs, including recommendations for signal analysis, how to discriminate rotor faults on fault patterns, and the particularities of two-pole SGs.