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RSS FeedsRegional Molecular Mapping of Primate Synapses during Normal Healthy Aging (Cell Reports)

 
 

23 april 2019 18:00:18

 
Regional Molecular Mapping of Primate Synapses during Normal Healthy Aging (Cell Reports)
 


Graham et al. reveal the regional heterogeneity of synaptic aging and how proteostatic alterations may dictate selective synaptic vulnerability. The authors use comparative proteomic profiling to identify microglial TGF-?1 signaling as a conserved upstream modulator of regional synaptic cascades during aging in both humans and non-human primates (NHPs).


 
55 viewsCategory: Cell Biology
 
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