Single-Cell Transcriptomics Analyses of Neural Stem Cell Heterogeneity and Contextual Plasticity in a Zebrafish Brain Model of Amyloid Toxicity (Cell Reports)

The zebrafish brain combats Alzheimer`s disease by producing more neurons, which are derived from neural stem cells. By using single-cell sequencing technology, Cosacak et al. identify distinct stem cell populations that react differently to Alzheimer`s disease-like conditions in the adult zebrafish brain and develop tools to investigate their molecular programs.