Transcriptomic Hallmarks of Tumor Plasticity and Stromal Interactions in Brain Metastasis (Cell Reports)

Wingrove et al. develop an RNA-sequencing-based approach to distinguish the tumor versus stromal transcriptomes in brain metastasis. This reveals the molecular plasticity of malignant cells and the neuroinflammatory response of the stroma in situ. Common tumor-stromal gene networks are also identified across different tumor types that form brain metastasis.