Natural Genetic Variation Reveals Key Features of Epigenetic and Transcriptional Memory in Virus-Specific CD8 T Cells (Immunity)

Van der Veeken et al. use naturally occurring cis-regulatory variation in wild-derived inbred mouse strains to dissect mechanisms of stable and reversible gene regulation in CD8 T cells. Their findings reveal central roles for T-box and Runx transcription factors and suggest a general mechanism for the formation of transcriptional and epigenetic memory.