Activation of Mast-Cell-Expressed Mas-Related G-Protein-Coupled Receptors Drives Non-histaminergic Itch (Immunity)

Classical itch studies have focused on IgE-mediated mast cell activation and histamine release. Meixiong et al. demonstrate that mast cell activation through the receptor Mrgprb2 contributes to non-histaminergic pruritus. Compared with IgE-Fc?RI signaling, Mrgprb2-activated mast cells released more tryptase and excited a distinct itch-sensory neuron population. Mast-cell-associated Mrgprs may be therapeutic targets for itch associated with allergic contact dermatitis.