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RSS FeedsIJMS, Vol. 20, Pages 2428: The L-Type Amino Acid Transporter LAT1--An Emerging Target in Cancer (International Journal of Molecular Sciences)

 
 

16 may 2019 17:01:46

 
IJMS, Vol. 20, Pages 2428: The L-Type Amino Acid Transporter LAT1--An Emerging Target in Cancer (International Journal of Molecular Sciences)
 


Chronic proliferation is a major hallmark of tumor cells. Rapidly proliferating cancer cells are highly dependent on nutrients in order to duplicate their cell mass during each cell division. In particular, essential amino acids are indispensable for proliferating cancer cells. Their uptake across the cell membrane is tightly controlled by membrane transporters. Among those, the L-type amino acid transporter LAT1 (SLC7A5) has been repeatedly found overexpressed in a vast variety of cancers. In this review, we summarize the most recent advances in our understanding of the role of LAT1 in cancer and highlight preclinical studies and drug developments underlying the potential of LAT1 as therapeutic target.


 
84 viewsCategory: Biochemistry, Biophysics, Molecular Biology
 
IJMS, Vol. 20, Pages 2429: The Impact of Maternal Fructose Exposure on Angiogenic Activity of Endothelial Progenitor Cells and Blood Flow Recovery After Critical Limb Ischemia in Rat Offspring (International Journal of Molecular Sciences)
IJMS, Vol. 20, Pages 2436: Green Tea Ameliorates Hyperglycemia by Promoting the Translocation of Glucose Transporter 4 in the Skeletal Muscle of Diabetic Rodents (International Journal of Molecular Sciences)
 
 
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