Pheromones and Nutritional Signals Regulate the Developmental Reliance on let-7 Family MicroRNAs in C. elegans (Current Biology)

Ilbay and Ambros show that pheromones and nutritional signals coordinately regulate developmental progression and cell-fate transitions during C. elegans development, and this coordination involves activation of an alternative temporal downregulation program for a critical let-7 family target, HBL-1.