This study presents the conditions and results of experimental investigations on various photovoltaic (PV) module cleaning methods and the effects on the performance of cadmium-telluride CdTe-type photovoltaic (PV) modules located in Doha, Qatar. The study aims to find the optimum cleaning technique and frequency based on cleaning performance and cost. PV modules are in a dusty and rocky area in the western part of Doha, Qatar within the north campus of Education City. Maximum power point tracking (MPPT) technology is employed for five different PV modules. The results show that microfiber-based wiper along with microfiber & vacuum cleaner are the most effective cleaning methods with about 6% improvement for the weekly period compared to the control panel among the considered methods. However, due to the increased cost of adding a vacuum cleaner, the microfiber-based wiper is the most efficient method when both cost and improvement rates are considered. In addition, the most efficient cleaning frequency (among daily, weekly and monthly) is found to be the weekly cleaning under the tested climate conditions.