Lateral segregation of palmitoyl ceramide-1-phosphate in simple and complex bilayers (Biophysical Journal)

Ceramide 1-phosphate (Cer-1P) is a sphingolipid with known functions in cell signalling. Knowledge about its biophysical properties in bilayers is limited. In our work, we have examined the lateral distribution of Cer-1P in fluid phosphatidylcholine bilayers, and compared its behavior with palmitoyl ceramide and palmitoyl sphingomyelin. Our findings confirm in part, and contradict in part, findings from previous studies on the subject. Our new information is helpful for better understanding of how physical properties relate to biological functions of Cer-1P.