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RSS FeedsIJMS, Vol. 20, Pages 2505: ERK is a Pivotal Player of Chemo-Immune-Resistance in Cancer (International Journal of Molecular Sciences)

 
 

21 may 2019 14:03:07

 
IJMS, Vol. 20, Pages 2505: ERK is a Pivotal Player of Chemo-Immune-Resistance in Cancer (International Journal of Molecular Sciences)
 




The extracellular signal-related kinases (ERKs) act as pleiotropic molecules in tumors, where they activate pro-survival pathways leading to cell proliferation and migration, as well as modulate apoptosis, differentiation, and senescence. Given its central role as sensor of extracellular signals, ERK transduction system is widely exploited by cancer cells subjected to environmental stresses, such as chemotherapy and anti-tumor activity of the host immune system. Aggressive tumors have a tremendous ability to adapt and survive in stressing and unfavorable conditions. The simultaneous resistance to chemotherapy and immune system responses is common, and ERK signaling plays a key role in both types of resistance. In this review, we dissect the main ERK-dependent mechanisms and feedback circuitries that simultaneously determine chemoresistance and immune-resistance/immune-escape in cancer cells. We discuss the pros and cons of targeting ERK signaling to induce chemo-immune-sensitization in refractory tumors.


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43 viewsCategory: Biochemistry, Biophysics, Molecular Biology
 
IJMS, Vol. 20, Pages 2504: MST1 Regulates Neuronal Cell Death via JNK/Casp3 Signaling Pathway in HFD Mouse Brain and HT22 Cells (International Journal of Molecular Sciences)
IJMS, Vol. 20, Pages 2503: Reduced Expression of CbUFO Is Associated with the Phenotype of a Flower-Defective Cosmos bipinnatus (International Journal of Molecular Sciences)
 
 
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