Transcription Restart Establishes Chromatin Accessibility after DNA Replication (Molecular Cell)

Accessibility is a hallmark of active chromatin. Stewart-Morgan et al. develop repli-ATAC-seq to profile accessibility after DNA replication and find that nascent chromatin is inaccessible to transcription machinery. Return of accessibility is heterogeneous across genomic features, independent of steady-state expression levels, and driven by resumption of transcription post-replication.