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21 may 2019 21:00:02

 
The Chimpanzee SIV Envelope Trimer: Structure and Deployment as an HIV Vaccine Template (Cell Reports)
 


Design of immunogens and strategies that can induce protective broadly neutralizing antibodies (bnAbs) is a priority for HIV vaccine development. Andrabi et al. design a chimpanzee simian immunodeficiency virus (SIV) envelope trimer immunogen that binds specifically to HIV V2-apex bnAbs and their unmutated versions. The SIV trimer immunogen induces HIV-specific neutralizing antibodies (nAbs) in a favorable animal model.


 
63 viewsCategory: Cell Biology
 
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