ZEB1 Represses Neural Differentiation and Cooperates with CTBP2 to Dynamically Regulate Cell Migration during Neocortex Development (Cell Reports)

Neural progenitor cells in the developing brain undergo a precisely controlled transition from proliferation to differentiation. Wang et al. report that ZEB1 expression is restricted to neural progenitor cells to ensure the transition to neuronal generation. Forced expression of ZEB1 blocks neuronal migration through interaction with CTBP2, leading to cortical abnormalities.