MyJournals Home  

RSS FeedsStructural flexibility of DNA-RNA hybrid duplex: stretching and twist-stretch coupling (Biophysical Journal)


23 may 2019 17:03:27

Structural flexibility of DNA-RNA hybrid duplex: stretching and twist-stretch coupling (Biophysical Journal)

DNA-RNA hybrid (DRH) duplexes are important intermediates in molecular biology and can play critical roles in the cell life. The flexibility of DRH duplexes can be important for their biological functions and may be very different from those of DNA and RNA duplexes. Here, we performed microsecond molecular dynamics simulations to quantitatively characterize the flexibility of DRH duplex in stretching and twist-stretch coupling. We found that a DRH duplex exhibits an intermediate conformation between A- and B-forms and closer to A-form. Furthermore, a DRH duplex has a stretch modulus of 83434pN and a weak twist-stretch coupling. Such different flexibility of DRH duplex from DNA and RNA duplexes in stretching and twist-stretch coupling is mainly attributed to its different base-pair inclination. Digg Facebook Google StumbleUpon Twitter
45 viewsCategory: Biophysics
Mechanism of Mycolactone Toxin Membrane Permeation: Atomistic vs Coarse-Grained MARTINI Simulations (Biophysical Journal)
Taking Simultaneous Snapshots of Intrinsically Disordered Proteins in Action (Biophysical Journal)
blog comments powered by Disqus
The latest issues of all your favorite science journals on one page


Register | Retrieve



Use these buttons to bookmark us: Digg Facebook Google StumbleUpon Twitter

Valid HTML 4.01 Transitional
Copyright © 2008 - 2020 Indigonet Services B.V.. Contact: Tim Hulsen. Read here our privacy notice.
Other websites of Indigonet Services B.V.: Nieuws Vacatures News Tweets Travel Photos Nachrichten Indigonet Finances Leer Mandarijn