MyJournals Home  

RSS FeedsOLIG2 Drives Abnormal Neurodevelopmental Phenotypes in Human iPSC-Based Organoid and Chimeric Mouse Models of Down Syndrome (Cell Stem Cell)

 
 

23 may 2019 18:03:34

 
OLIG2 Drives Abnormal Neurodevelopmental Phenotypes in Human iPSC-Based Organoid and Chimeric Mouse Models of Down Syndrome (Cell Stem Cell)
 


Using Down syndrome (DS) human iPSC brain organoid and neuronal chimeric mouse brain models, Xu et al. demonstrate that upregulated expression of OLIG2 in DS neural progenitors causes overproduction of subclass-specific GABAergic interneurons. Reducing OLIG2 expression restores interneuron differentiation and improves recognition memory in DS chimeric mice.


 
76 viewsCategory: Cell Biology
 
Probing the Tumor Suppressor Function of BAP1 in CRISPR-Engineered Human Liver Organoids (Cell Stem Cell)
Two Distinct E2F Transcriptional Modules Drive Cell Cycles and Differentiation (Cell Reports)
 
 
blog comments powered by Disqus


MyJournals.org
The latest issues of all your favorite science journals on one page

Username:
Password:

Register | Retrieve

Search:

Cell Biology


Copyright © 2008 - 2024 Indigonet Services B.V.. Contact: Tim Hulsen. Read here our privacy notice.
Other websites of Indigonet Services B.V.: Nieuws Vacatures News Tweets Nachrichten