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RSS FeedsA Secreted Viral Nonstructural Protein Determines Intestinal Norovirus Pathogenesis (Cell Host & Microbe)

 
 

23 may 2019 19:03:20

 
A Secreted Viral Nonstructural Protein Determines Intestinal Norovirus Pathogenesis (Cell Host & Microbe)
 


Norovirus is an enteric virus that infects intestinal epithelial tuft cells in mice. Lee et al. discover that murine norovirus NS1 is an unconventionally secreted protein that overcomes IFN-?-mediated norovirus control and is critical for intestinal infection in mice. Additionally, vaccination with NS1 alone confers protection, suggesting potential vaccine strategies.


 
96 viewsCategory: Cell Biology, Immunology, Microbiology
 
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