Nutrient Sensing in CD11c Cells Alters the Gut Microbiota to Regulate Food Intake and Body Mass (Cell Metabolism)

Chagwedera et al. report that mTORC1 activation in CD11c cells reduces food intake and body weight in lean mice. The transfer of microbiota from control animals, in particular L. johnsonii Q1-7, rescues the phenotype, suggesting the existence of transkingdom immune-microbiota circuits for homeostatic regulation of food intake and body mass in response to nutrient sensing in healthy mice.