Targeted Degradation of a Hypoxia-Associated Non-coding RNA Enhances the Selectivity of a Small Molecule Interacting with RNA (Cell Chemical Biology)

Costales et al. study the selectivity of a bifunctional molecule that binds a hypoxia-associated microRNA and recruits local latent ribonuclease, enabling its targeted degradation and apoptosis in breast cancer cells. Applying this chimeric recruitment strategy increases potency and the selectivity window compared with the parent compound.