Time-Variant SRC Kinase Activation Determines Endothelial Permeability Response (Cell Chemical Biology)

Klomp et al. used a chemically inducible kinase system and physiological stimuli to demonstrate SRC kinase regulates the endothelial barrier in a temporally dependent manner. SRC activity initially enhances barrier function via the adherens junction protein VE cadherin, while prolonged activity leads to endothelial barrier disruption.