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RSS FeedsIJMS, Vol. 20, Pages 2833: Contribution of Impaired Insulin Signaling to the Pathogenesis of Diabetic Cardiomyopathy (International Journal of Molecular Sciences)

 
 

11 june 2019 09:00:32

 
IJMS, Vol. 20, Pages 2833: Contribution of Impaired Insulin Signaling to the Pathogenesis of Diabetic Cardiomyopathy (International Journal of Molecular Sciences)
 


Diabetic cardiomyopathy (DCM) has emerged as a relevant cause of heart failure among the diabetic population. Defined as a cardiac dysfunction that develops in diabetic patients independently of other major cardiovascular risks factors, such as high blood pressure and coronary artery disease, the underlying cause of DCMremains to be unveiled. Several pathogenic factors, including glucose and lipid toxicity, mitochondrial dysfunction, increased oxidative stress, sustained activation of the renin-angiotensin system (RAS) or altered calcium homeostasis, have been shown to contribute to the structural and functional alterations that characterize diabetic hearts. However, all these pathogenic mechanisms appear to stem from the metabolic inflexibility imposed by insulin resistance or lack of insulin signaling. This results in absolute reliance on fatty acids for the synthesis of ATP and impairment of glucose oxidation. Glucose is then rerouted to other metabolic pathways, with harmful effects on cardiomyocyte function. Here, we discuss the role that impaired cardiac insulin signaling in diabetic or insulin-resistant individuals plays in the onset and progression of DCM.


 
70 viewsCategory: Biochemistry, Biophysics, Molecular Biology
 
IJMS, Vol. 20, Pages 2834: IRTKS Promotes Insulin Signaling Transduction through Inhibiting SHIP2 Phosphatase Activity (International Journal of Molecular Sciences)
IJMS, Vol. 20, Pages 2850: Lysophosphatidic Acid Signaling in Diabetic Nephropathy (International Journal of Molecular Sciences)
 
 
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