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RSS FeedsMarine Drugs, Vol. 17, Pages 353: Kabirimine, a New Cyclic Imine from an Okinawan Dinoflagellate (Marine Drugs)

 
 

14 june 2019 04:00:24

 
Marine Drugs, Vol. 17, Pages 353: Kabirimine, a New Cyclic Imine from an Okinawan Dinoflagellate (Marine Drugs)
 


On our quest for new bioactive molecules from marine sources, two cyclic imines (1, 2) were isolated from a dinoflagellate extract, inhibiting the growth of the respiratory syncytial virus (RSV). Compound 1 was identified as a known molecule portimine, while 2 was elucidated to be a new cyclic imine, named kabirimine. The absolute stereochemistry of 1 was determined by crystallographic work and chiral derivatization, whereas the structure of 2 was elucidated by means of spectroscopic analysis and computational study on all the possible isomers. Compound 1 showed potent cytotoxicity (CC50 < 0.097 µM) against HEp2 cells, while 2 exhibited moderate antiviral activity against RSV with IC50 = 4.20 µM (95% CI 3.31–5.33).


 
65 viewsCategory: Biochemistry, Molecular Biology, Pharmacology
 
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Marine Drugs, Vol. 17, Pages 356: Bostrychines A-F, Six Novel Mycosporine-Like Amino-Acids and a Novel Betaine from the Red Alga Bostrychia scorpioides (Marine Drugs)
 
 
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