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RSS FeedsKinetic stability of long-lived human lens ?-crystallins and their isolated double Greek Key domains (Biophysical Journal)

 
 

14 june 2019 11:03:14

 
Kinetic stability of long-lived human lens ?-crystallins and their isolated double Greek Key domains (Biophysical Journal)
 


The ?-crystallins of the eye lens nucleus are among the longest-lived proteins in the human body. Synthesized in utero, they must remain folded and soluble throughout adulthood to maintain lens transparency and avoid cataracts. ?D- and ?S-crystallin are two major monomeric crystallins of the human lens. ?D-crystallin is concentrated in the oldest lens fiber cells, the lens nucleus, while ?S-crystallin is concentrated in the younger cells of the lens cortex. The kinetic stability parameters of these two-domain proteins and their isolated domains were determined and compared.


 
57 viewsCategory: Biophysics
 
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