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RSS FeedsIJMS, Vol. 20, Pages 2952: Diversity and Function of Somatostatin-Expressing Interneurons in the Cerebral Cortex (International Journal of Molecular Sciences)

 
 

17 june 2019 12:03:56

 
IJMS, Vol. 20, Pages 2952: Diversity and Function of Somatostatin-Expressing Interneurons in the Cerebral Cortex (International Journal of Molecular Sciences)
 




Inhibitory interneurons make up around 10–20% of the total neuron population in the cerebral cortex. A hallmark of inhibitory interneurons is their remarkable diversity in terms of morphology, synaptic connectivity, electrophysiological and neurochemical properties. It is generally understood that there are three distinct and non-overlapping interneuron classes in the mouse neocortex, namely, parvalbumin-expressing, 5-HT3A receptor-expressing and somatostatin-expressing interneuron classes. Each class is, in turn, composed of a multitude of subclasses, resulting in a growing number of interneuron classes and subclasses. In this review, I will focus on the diversity of somatostatin-expressing interneurons (SOM+ INs) in the cerebral cortex and elucidate their function in cortical circuits. I will then discuss pathological consequences of a malfunctioning of SOM+ INs in neurological disorders such as major depressive disorder, and present future avenues in SOM research and brain pathologies.


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39 viewsCategory: Biochemistry, Biophysics, Molecular Biology
 
IJMS, Vol. 20, Pages 2954: A Transparency Sheet-Based Colorimetric Device for Simple Determination of Calcium Ions Using Induced Aggregation of Modified Gold Nanoparticles (International Journal of Molecular Sciences)
IJMS, Vol. 20, Pages 2951: Phenolic Compounds and Ginsenosides in Ginseng Shoots and Their Antioxidant and Anti-Inflammatory Capacities in LPS-Induced RAW264.7 Mouse Macrophages (International Journal of Molecular Sciences)
 
 
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