Neuronally Enriched RUFY3 Is Required for Caspase-Mediated Axon Degeneration (Neuron)

Hertz et al. identify the neuronally enriched protein RUFY3 as a key regulator downstream of (or in parallel to) caspase-3 in axon degeneration. RUFY3 is dephosphorylated and cleaved during degeneration. RUFY3 may provide a neuron-specific control point for neurons to locally control axon degeneration.