With the goal of increasing energy efficiency and passenger comfort in an automobile cabin, we developed a regional air-conditioning design to control cold air in specific regions, and an air management strategy that can keep air circulation when the car engine cuts out. According to computational simulations, an air velocity of 2 m/s was adopted, which could form an independent flow field space in the cabin with a temperature gap of 7 °C according to the user’s needs. The designed regional air-conditioning and circulation system could create independent flow field spaces with temperature differences. Inlet air volume demand was also reduced by 60% and blower power by 53 W. In addition, the cabin ventilation system led air exchange rate reached 89% per hour. In 20 min of exposure under sun, the system could lower the cabin temperature by 12.3 °C.