HCF-1 Regulates De Novo Lipogenesis through a Nutrient-Sensitive Complex with ChREBP (Molecular Cell)

Lane et al. identify HCF-1 as a ChREBP-modulatory protein relevant for de novo lipogenesis. Glucose stimulation triggers HCF-1 O-GlcNAcylation, priming its association with ChREBP and OGT recruitment for ChREBP O-GlcNAcylation and increased ChREBP transcriptional activity. The HCF-1:ChREBP complex imparts glucose-dependent epigenetic regulation to lipogenic promoters by recruiting epigenetic modifiers.