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RSS FeedsDurable Response of Enzalutamide-resistant Prostate Cancer to Supraphysiological Testosterone Is Associated with a Multifaceted Growth Suppression and Impaired DNA Damage Response Transcriptomic Program in Patient-derived Xenografts (European Urology)

 
 

20 june 2019 00:02:48

 
Durable Response of Enzalutamide-resistant Prostate Cancer to Supraphysiological Testosterone Is Associated with a Multifaceted Growth Suppression and Impaired DNA Damage Response Transcriptomic Program in Patient-derived Xenografts (European Urology)
 




Supraphysiological testosterone (SPT) produces clinical and quality-of-life benefits in subsets of castration-resistant prostate cancer patients. Molecular characteristics associated with a response have not been identified yet. This study indicated sustained repressions of ARv7 and E2F transcriptional outputs, and the DNA damage response program as hallmarks of a durable SPT response.


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63 viewsCategory: Urology
 
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