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RSS FeedsIJMS, Vol. 20, Pages 3056: The Potential of Flavonoids for the Treatment of Neurodegenerative Diseases (International Journal of Molecular Sciences)

 
 

22 june 2019 13:02:47

 
IJMS, Vol. 20, Pages 3056: The Potential of Flavonoids for the Treatment of Neurodegenerative Diseases (International Journal of Molecular Sciences)
 


Neurodegenerative diseases, including Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), and amyotrophic lateral sclerosis (ALS), currently affect more than 6 million people in the United States. Unfortunately, there are no treatments that slow or prevent disease development and progression. Regardless of the underlying cause of the disorder, age is the strongest risk factor for developing these maladies, suggesting that changes that occur in the aging brain put it at increased risk for neurodegenerative disease development. Moreover, since there are a number of different changes that occur in the aging brain, it is unlikely that targeting a single change is going to be effective for disease treatment. Thus, compounds that have multiple biological activities that can impact the various age-associated changes in the brain that contribute to neurodegenerative disease development and progression are needed. The plant-derived flavonoids have a wide range of activities that could make them particularly effective for blocking the age-associated toxicity pathways associated with neurodegenerative diseases. In this review, the evidence for beneficial effects of multiple flavonoids in models of AD, PD, HD, and ALS is presented and common mechanisms of action are identified. Overall, the preclinical data strongly support further investigation of specific flavonoids for the treatment of neurodegenerative diseases.


 
68 viewsCategory: Biochemistry, Biophysics, Molecular Biology
 
IJMS, Vol. 20, Pages 3059: New Lectins from Mediterranean Flora. Activity against HT29 Colon Cancer Cells (International Journal of Molecular Sciences)
IJMS, Vol. 20, Pages 3052: Class I-Histone Deacetylase (HDAC) Inhibition is Superior to pan-HDAC Inhibition in Modulating Cisplatin Potency in High Grade Serous Ovarian Cancer Cell Lines (International Journal of Molecular Sciences)
 
 
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