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RSS FeedsIJMS, Vol. 20, Pages 3061: Anti-Inflammatory Activities of Marine Algae in Neurodegenerative Diseases (International Journal of Molecular Sciences)

 
 

22 june 2019 18:02:35

 
IJMS, Vol. 20, Pages 3061: Anti-Inflammatory Activities of Marine Algae in Neurodegenerative Diseases (International Journal of Molecular Sciences)
 


Neuroinflammation is one of the main contributors to the onset and progression of neurodegenerative diseases such as Alzheimer’s and Parkinson’s diseases. Microglial and astrocyte activation is a brain defense mechanism to counteract harmful pathogens and damaged tissues, while their prolonged activation induces neuroinflammation that can trigger or exacerbate neurodegeneration. Unfortunately, to date there are no pharmacological therapies able to slow down or stop the progression of neurodegeneration. For this reason, research is turning to the identification of natural compounds with protective action against these diseases. Considering the important role of neuroinflammation in the onset and development of neurodegenerative pathologies, natural compounds with anti-inflammatory activity could be good candidates for developing effective therapeutic strategies. Marine organisms represent a huge source of natural compounds, and among them, algae are appreciated sources of important bioactive components such as antioxidants, proteins, vitamins, minerals, soluble dietary fibers, polyunsaturated fatty acids, polysaccharides, sterols, carotenoids, tocopherols, terpenes, phycobilins, phycocolloids, and phycocyanins. Recently, numerous anti-inflammatory compounds have been isolated from marine algae with potential protective efficacy against neuroinflammation. This review highlights the key inflammatory processes involved in neurodegeneration and the potential of specific compounds from marine algae to counteract neuroinflammation in the CNS.


 
116 viewsCategory: Biochemistry, Biophysics, Molecular Biology
 
IJMS, Vol. 20, Pages 3060: A Novel PL9 Pectate Lyase from Paenibacillus polymyxa KF-1: Cloning, Expression, and Its Application in Pectin Degradation (International Journal of Molecular Sciences)
IJMS, Vol. 20, Pages 3065: Post-Mortem Immunohistochemical Evidence of ?2-Adrenergic Receptor Expression in the Adrenal Gland (International Journal of Molecular Sciences)
 
 
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