MyJournals Home  

RSS FeedsIJMS, Vol. 20, Pages 3077: Post-Translational Modification-Dependent Activity of Matrix Metalloproteinases (International Journal of Molecular Sciences)

 
 

24 june 2019 21:02:25

 
IJMS, Vol. 20, Pages 3077: Post-Translational Modification-Dependent Activity of Matrix Metalloproteinases (International Journal of Molecular Sciences)
 




Due to their capacity to process different proteins of the extracellular matrix (ECM), matrix metalloproteinases (MMPs) were initially described as a family of secreted proteases, functioning as main ECM regulators. However, through proteolytic processing of various biomolecules, MMPs also modulate intra- and extracellular pathways and networks. Thereby, they are functionally implicated in the regulation of multiple physiological and pathological processes. Consequently, MMP activity is tightly regulated through a combination of epigenetic, transcriptional, and post-transcriptional control of gene expression, proteolytic activation, post-translational modifications (PTMs), and extracellular inhibition. In addition, MMPs, their substrates and ECM binding partners are frequently modified by PTMs, which suggests an important role of PTMs in modulating the pleiotropic activities of these proteases. This review summarizes the recent progress towards understanding the role of PTMs (glycosylation, phosphorylation, glycosaminoglycans) on the activity of several members of the MMP family.


Del.icio.us Digg Facebook Google StumbleUpon Twitter
 
59 viewsCategory: Biochemistry, Biophysics, Molecular Biology
 
IJMS, Vol. 20, Pages 3076: Role of Hedgehog Signaling in Vasculature Development, Differentiation, and Maintenance (International Journal of Molecular Sciences)
IJMS, Vol. 20, Pages 3075: Physiological Significance of the Force-Velocity Relation in Skeletal Muscle and Muscle Fibers (International Journal of Molecular Sciences)
 
 
blog comments powered by Disqus


MyJournals.org
The latest issues of all your favorite science journals on one page

Username:
Password:

Register | Retrieve

Search:

Molecular Biology

Use these buttons to bookmark us:
Del.icio.us Digg Facebook Google StumbleUpon Twitter


Valid HTML 4.01 Transitional
Copyright © 2008 - 2019 Indigonet Services B.V.. Contact: Tim Hulsen. Read here our privacy notice.
Other websites of Indigonet Services B.V.: Nieuws Vacatures News Tweets Travel Photos Nachrichten Indigonet Finances Leer Mandarijn