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RSS FeedsIJMS, Vol. 20, Pages 3097: Age-Associated mRNA and miRNA Expression Changes in the Blood-Brain Barrier (International Journal of Molecular Sciences)

 
 

25 june 2019 13:02:26

 
IJMS, Vol. 20, Pages 3097: Age-Associated mRNA and miRNA Expression Changes in the Blood-Brain Barrier (International Journal of Molecular Sciences)
 


Functional and structural age-associated changes in the blood-brain barrier (BBB) may affect the neurovascular unit and contribute to the onset and progression of age-associated neurodegenerative pathologies, including Alzheimer’s disease. The current study interrogated the RNA profile of the BBB in an ageing human autopsy brain cohort and an ageing mouse model using combined laser capture microdissection and expression profiling. Only 12 overlapping genes were altered in the same direction in the BBB of both ageing human and mouse cohorts. These included genes with roles in regulating vascular tone, tight junction protein expression and cell adhesion, all processes prone to dysregulation with advancing age. Integrated mRNA and miRNA network and pathway enrichment analysis of the datasets identified 15 overlapping miRNAs that showed altered expression. In addition to targeting genes related to DNA binding and/or autophagy, many of the miRNAs identified play a role in age-relevant processes, including BBB dysfunction and regulating the neuroinflammatory response. Future studies have the potential to develop targeted therapeutic approaches against these candidates to prevent vascular dysfunction in the ageing brain.


 
88 viewsCategory: Biochemistry, Biophysics, Molecular Biology
 
IJMS, Vol. 20, Pages 3098: A Free-Operant Reward-Tracking Paradigm to Study Neural Mechanisms and Neurochemical Modulation of Adaptive Behavior in Rats (International Journal of Molecular Sciences)
IJMS, Vol. 20, Pages 3096: Serum Proteome Alterations in Human Cystathionine ?-Synthase Deficiency and Ischemic Stroke Subtypes (International Journal of Molecular Sciences)
 
 
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