Early Seizure Activity Accelerates Depletion of Hippocampal Neural Stem Cells and Impairs Spatial Discrimination in an Alzheimer`s Disease Model (Cell Reports)

The mechanisms that alter hippocampal neurogenesis in AD patients and mice are unclear. Fu et al. show that in a transgenic mouse model, spontaneous seizures stimulate neural stem cell (NSC) proliferation and accelerate depletion of a finite NSC pool. This process leads to neurogenesis that is increased early but decreased later in disease, coinciding with spatial discrimination deficits.