Aquaporin-4 Surface Trafficking Regulates Astrocytic Process Motility and Synaptic Activity in Health and Autoimmune Disease (Cell Reports)

Ciappelloni et al. use fluorescent imaging approaches to investigate how astrocytes control their highly ramified processes. The membrane dynamics and distribution of aquaporin-4 (AQP4) subtypes control the motility of astrocyte processes, influencing the physiological interplay between astrocyte and neurons. This regulation is targeted by autoantibodies from NMO patients.