Physical and Molecular Landscapes of Mouse Glioma Extracellular Vesicles Define Heterogeneity (Cell Reports)

Extracellular vesicles (EVs) are highly heterogeneous. Using genetically defined mouse glioblastoma tumor cells, Gyuris et al. employ a differential filtration approach to isolate EVs based on size and establish the differential distribution of RNA and protein between EVs and ribonucleoprotein complexes in genetically distinct contexts.