Genome-wide Transcript Structure Resolution Reveals Abundant Alternate Isoform Usage from Murine Gammaherpesvirus 68 (Cell Reports)

The highly dense dsDNA genomes of herpesviruses feature an abundance of overlapping transcripts and extensive splicing, greatly hindering the global identification of individual transcripts. O`Grady et al. use integrated multi-platform genomics to globally resolve transcript structures from murine gammaherpesvirus 68, providing an extensively revised genome annotation.