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17 july 2019 06:02:33

 
ABCE1 Controls Ribosome Recycling by an Asymmetric Dynamic Conformational Equilibrium (Cell Reports)
 


Gouridis et al. delineate the inner workings of ABCE1 by single-molecule FRET, demonstrating that the two asymmetric nucleotide-binding sites functionally and conformationally adopt distinct states during ribosome recycling. Unexpectedly, both sites are found in a dynamic equilibrium of conformational states governed by ribosomes, nucleotides, and release factors.


 
246 viewsCategory: Cell Biology
 
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