Conversion of Astrocytes and Fibroblasts into Functional Noradrenergic Neurons (Cell Reports)

Li et al. identified seven transcription factors that convert mouse astrocytes, fibroblasts, and human fibroblasts into induced noradrenergic (iNA) neurons. The iNA neurons are functional and integrate into neural circuits after transplantation. Single-cell RNA sequencing results showed that the transcriptome of iNA neurons converted from astrocytes and fibroblast are similar.