Molecular Basis for Control of Diverse Genome Stability Factors by the Multi-BRCT Scaffold Rtt107 (Molecular Cell)

Di-BRCT domains recognize phospho-proteins and contribute to the DNA damage response. Wan et al. show that a distinct architecture formed by four BRCTs of the Rtt107 protein enables recognition of phospho-free ligands and supports constitutive genome protection. This work uncovers structural plasticity and functional diversity of BRCT domains.