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RSS FeedsIJMS, Vol. 20, Pages 3511: An Ensemble Classifier to Predict Protein-Protein Interactions by Combining PSSM-based Evolutionary Information with Local Binary Pattern Model (International Journal of Molecular Sciences)

 
 

17 july 2019 16:03:27

 
IJMS, Vol. 20, Pages 3511: An Ensemble Classifier to Predict Protein-Protein Interactions by Combining PSSM-based Evolutionary Information with Local Binary Pattern Model (International Journal of Molecular Sciences)
 


Protein plays a critical role in the regulation of biological cell functions. Among them, whether proteins interact with each other has become a fundamental problem, because proteins usually perform their functions by interacting with other proteins. Although a large amount of protein–protein interactions (PPIs) data has been produced by high-throughput biotechnology, the disadvantage of biological experimental technique is time-consuming and costly. Thus, computational methods for predicting protein interactions have become a research hot spot. In this research, we propose an efficient computational method that combines Rotation Forest (RF) classifier with Local Binary Pattern (LBP) feature extraction method to predict PPIs from the perspective of Position-Specific Scoring Matrix (PSSM). The proposed method has achieved superior performance in predicting Yeast, Human, and H. pylori datasets with average accuracies of 92.12%, 96.21%, and 86.59%, respectively. In addition, we also evaluated the performance of the proposed method on the four independent datasets of C. elegans, H. pylori, H. sapiens, and M. musculus datasets. These obtained experimental results fully prove that our model has good feasibility and robustness in predicting PPIs.


 
205 viewsCategory: Biochemistry, Biophysics, Molecular Biology
 
IJMS, Vol. 20, Pages 3504: Pathway-Centric Structure-Based Multi-Target Compound Screening for Anti-Virulence Drug Repurposing (International Journal of Molecular Sciences)
IJMS, Vol. 20, Pages 3510: Suppression of Propionibacterium acnes-Induced Skin Inflammation by Laurus nobilis Extract and Its Major Constituent Eucalyptol (International Journal of Molecular Sciences)
 
 
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