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RSS FeedsPI31 Is an Adaptor Protein for Proteasome Transport in Axons and Required for Synaptic Development (Developmental Cell)

 
 

18 july 2019 19:05:02

 
PI31 Is an Adaptor Protein for Proteasome Transport in Axons and Required for Synaptic Development (Developmental Cell)
 


Proteasomes are actively transported between the soma and terminals of neurons. Liu et al. show that PI31 couples proteasomes to cellular motors for fast axonal transport and thereby brings proteasomes to sites where protein breakdown occurs. This mechanism is required for protein homeostasis and synaptic architecture.


 
166 viewsCategory: Cell Biology
 
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