Structural Adaptation in Its Orphan Domain Engenders Betaglycan with an Alternate Mode of Growth Factor Binding Relative to Endoglin (Structure)

Kim et al. determine the structure of the betaglycan orphan domain (BGO) and show that the edge ? strand that endoglin uses to bind its cognate growth factor is blocked by an insertion. Binding studies and SAXS show that BGO binds its cognate growth factor differently compared with endoglin.