HokB Monomerization and Membrane Repolarization Control Persister Awakening (Molecular Cell)

Wilmaerts et al. demonstrate that the toxin HokB forms intermolecular disulfide bridges, which are essential for HokB pore formation and consequently the induction of persistence. In addition, they show that the awakening of these persister cells relies on the monomerization of the HokB toxin, combined with repolarization of the membrane.