m5C Methylation Guides Systemic Transport of Messenger RNA over Graft Junctions in Plants (Current Biology)

In plants, thousands of messenger RNAs move to distant body parts to potentially act as systemic signals. Yang, Pererra, et al. show that 5-methylcytosine (m5C) modification of mobile RNA plays a crucial role in facilitating their transport and present evidence that mobile m5C-modified TCTP1 is translated in target cells and changes root growth.