Defining the Identity and Dynamics of Adult Gastric Isthmus Stem Cells (Cell Stem Cell)

Using lineage-tracing assays and single-cell gene expression profiling, Han et al. show that the mouse gastric corpus gland is compartmentalized, with base and isthmus regions supported by two separate independent stem cell populations. Isthmus stem cells are rapidly cycling, with a broad expression signature, and undergo `punctuated` neutral drift dynamics.