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RSS FeedsTransient Activations of Rac1 at the Lamellipodium Tip Trigger Membrane Protrusion (Current Biology)

 
 

16 august 2019 00:01:21

 
Transient Activations of Rac1 at the Lamellipodium Tip Trigger Membrane Protrusion (Current Biology)
 


Mehidi et al. use single protein tracking with loss- or gain-of-function mutants of Rho GTPases to reveal that transient Rac1 immobilization at the lamellipodium tip correlates with its activation and binding to effectors. Short-lived activations ensure a local and rapid control of Rac1 actions on its effectors to trigger actin-based protrusion.


 
184 viewsCategory: Biology
 
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