Transient Internalization and Microtubule-Dependent Trafficking of a Ciliary Signaling Receptor from the Plasma Membrane to the Cilium (Current Biology)

Ranjan et al. identify a pathway for regulated transit of ciliary receptors from the plasma membrane to the ciliary membrane in the bi-ciliated alga Chlamydomonas. Within minutes after signaling is triggered, receptors are internalized from the plasma membrane, align along cytoplasmic microtubules, and re-appear on the membrane at the ciliary base.