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RSS FeedsIJERPH, Vol. 16, Pages 2995: Levels of Urinary Biomarkers of Oxidatively Generated Damage to DNA and RNA in Different Groups of Workers Compared to General Population (International Journal of Environmental Research and Public Health)

 
 

20 august 2019 12:01:47

 
IJERPH, Vol. 16, Pages 2995: Levels of Urinary Biomarkers of Oxidatively Generated Damage to DNA and RNA in Different Groups of Workers Compared to General Population (International Journal of Environmental Research and Public Health)
 




(1) Background: The products of guanine oxidation in DNA and RNA excreted in urine are 8-oxo-7,8-dihydroguanine (8-oxoGua), 8-oxo-7,8-dihydroguanosine (8-oxoGuo), and 8-oxo-7,8-dihydro-2’-deoxyguanosine (8-oxodGuo). Despite intra and inter-individual variability, it is possible to identify situations that significantly increase the levels of these compounds when comparing urinary concentrations of some workers to those of the general population. (2) Methods: urines from gasoline pump attendants (58 from Saudi Arabia and 102 from Italy), 24 workers of a fiberglass reinforced plastics plant, 17 painters and 6 divers were analyzed by HPLC/MS-MS. To test the individual variability, two subjects provided daily samples for one month, and 132 urine samples from the general population were analyzed. (3) Results: We summarized the results for each biomarker, and found the following were statistically higher than in the general population: 8-oxoGua in fiberglass and Italian gasoline workers; 8-oxodGuo in fiberglass and both Saudi Arabian and Italian gasoline workers; 8-oxoGuo in fiberglass workers, both Saudi Arabian and Italian gasoline workers, and painters after the working shift. (4) Conclusions: these results confirm that both 8-oxodGuo and 8-oxoGuo are valuable biomarkers for occupational exposures to dangerous chemicals and seem to suggest that 8-oxoGuo, related to RNA oxidation, is a suitable biomarker to evaluate short term, reversible effects of occupational exposures even within the health-based limit values.


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104 viewsCategory: Medicine, Pathology, Toxicology
 
IJERPH, Vol. 16, Pages 2983: The Impact of Particulate Matter on Outdoor Activity and Mental Health: A Matching Approach (International Journal of Environmental Research and Public Health)
IJERPH, Vol. 16, Pages 2994: Dental Caries and the Erosive Tooth Wear Status of 12-Year-Old Children in Jakarta, Indonesia (International Journal of Environmental Research and Public Health)
 
 
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