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RSS FeedsConserved Pseudoknots in lncRNA MEG3 Are Essential for Stimulation of the p53 Pathway (Molecular Cell)

 
 

20 august 2019 19:02:30

 
Conserved Pseudoknots in lncRNA MEG3 Are Essential for Stimulation of the p53 Pathway (Molecular Cell)
 




Uroda et al. identify the structural and functional core of the human lncRNA MEG3, revealing that point mutations designed to disrupt the MEG3 fold impair function. The work proves the importance of lncRNA tertiary structure motifs for selective and specific control of key cellular processes such as the p53 stress response.


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19 viewsCategory: Molecular Biology, Cell Biology
 
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