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RSS FeedsEvolution of Inosine-Specific Endonuclease V from Bacterial DNase to Eukaryotic RNase (Molecular Cell)

 
 

20 august 2019 19:02:30

 
Evolution of Inosine-Specific Endonuclease V from Bacterial DNase to Eukaryotic RNase (Molecular Cell)
 


Wu et al. show that bacterial Endonuclease V (EndoV) cleaves DNA in the presence of an inosine (deaminated adenosine), but eukaryotic EndoV, due to insertions in two non-conserved loops, cleaves inosine-containing RNA only. A similar DNA-to-RNA evolution also occurs in Argonaute.


 
264 viewsCategory: Molecular Biology, Cell Biology
 
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